| 2015 | Cordyceps militaris | The Efficacy and Safety of Cordyceps militaris in Korean Adults Who Have Mild Liver Dysfunction | 54 | Fruiting Body | 1500 mg/day | |
| 2015 | Cordyceps militaris | Cordyceps militaris Enhances Cell-Mediated Immunity in Healthy Korean Men | 79 | Fruiting Body Ethanol Extract | 1500 mg/day | |
| 2016 | Cordyceps militaris | Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation | 28 | Mix including Myceliated Biomass (oats) | 619 mg/day | |
| 2019 | Cordyceps militaris | Effects of Cordyceps militaris supplementation on the immune response and upper respiratory infection in healthy adults- a randomized, double-blind, placebo-controlled study | 100 | Fruiting Body | 300 mg/day | |
| 2021 | Cordyceps militaris | Efficacy and Safety of Cordyceps militaris as an Adjuvant to Duloxetine in the Treatment of Insomnia in Patients With Depression: A 6-Week Double-Blind, Randomized, Placebo-Controlled Trial | 59 | Fruiting Body | 3000 mg/day | |
| 2022 | Cordyceps militaris | The effects of Cordyceps militaris fruiting bodies in micturition and prostate size in benign prostatic hyperplasia patients- A pilot study | 62 | Fruiting Body | 250 mg twice daily | |
| 2023 | Cordyceps militaris | Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation | 65 | Fruiting Body | 500 mg three times a day | |
| 2024 | Cordyceps militaris | Improved Oxygen Saturation and Performance of Athletes using Cordyceps militaris | 48 | Fruiting Body | 1000 mg/day | |
| 2020 | Grifola gargal | Medicinal Mushroom, Grifola gargal, Lowers Triglyceride in Animal Models of Obesity and Diabetes and in Adults with Prediabetes | 10 | Fruiting Body extract | 9200 mg/day | |
| 2009 | Lions Mane (Hericium erinaceus) | Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment | 30 | Fruiting Body | 1000 mg/day | |
| 2010 | Lions Mane (Hericium erinaceus) | Reduction of Depression and Anxiety by 4 Weeks Hericium erinaceus Intake | 30 | Fruiting Body | 500 mg/day | |
| 2015 | Lions Mane (Hericium erinaceus) | The Effects of Hericium erinaceus (Amyloban® 3399) on Sleep Quality and Subjective Well-being | 8 | Amyloban® 3399 (with Hericenone A) | – | |
| 2019 | Lions Mane (Hericium erinaceus) | Improvement of Cognitive Functions by Oral Intake of Hericium erinaceus | 31 | Fruiting Body | 3200 mg/day | |
| 2019 | Lions Mane (Hericium erinaceus) | Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity | 77 | Fruiting Body (20%) and Mycelium (80%) | – | |
| 2020 | Lions Mane (Hericium erinaceus) | Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia | 41 | Mycelium Enriched With Erinacine A A | 1050 mg/day (with 15 mg/day of Erinacine A A) | |
| 2021 | Lions Mane (Hericium erinaceus) | Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers | 13 | Mycelium Extract | 3000 mg | |
| 2022 | Lions Mane (Hericium erinaceus) | Effects of Erinacine A-Enriched Hericium erinaceus on Elderly Hearing-Impaired Patients | 80 | Mycelium Enriched With Erinacine A A | 2000 mg/day (with 10 mg/day of Erinacine A A) | |
| 2023 | Lions Mane (Hericium erinaceus) | The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults | 41 | Fruiting Body and Mycelium | 1800 mg/day | |
| 2000 | Maitake (Grifola frondosa) | Effects of Maitake (Grifola frondosa) glucan in HIV-infected patients | 35 | Fruiting Body and/or MD-Fraction | 6000 mg/day or 20 mg +4000 mg/day | |
| 2003 | Maitake (Grifola frondosa) | Effect of Maitake (Grifola frondosa) D-Fraction on the Activation of NK Cells in Cancer Patients | 10 | D-Fraction | 80-300 mg/day | |
| 2004 | Maitake (Grifola frondosa) | Safety of Maitake D-Fraction in Healthy Patients | 28 | D-Fraction | 1 Drop/Kg Body Weight | |
| 2009 | Maitake (Grifola frondosa) | A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects | 34 | Fruiting Body Extract | 2-20 mg/day | |
| 2010 | Maitake (Grifola frondosa) | Maitake Mushroom (Grifola frondosa) Extract Induces Ovulation in Patients with Polycystic Ovary Syndrome | 80 | Extract | 162 mg/day | |
| 2015 | Maitake (Grifola frondosa) | Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study | 21 | Fruiting Body Extract | 6 mg/day | |
| 2022 | Maitake (Grifola frondosa) | Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial | 141 | D-Fraction | 3000 mg/day | |
| 1999 | Ophiocordyceps sinensis | Increased Aerobic Capacity in Healthy Elderly Humans Given a Fermentation Product of Cordyceps CS-4 | 30 | CS-4 | 3000 mg/day | |
| 2001 | Ophiocordyceps sinensis | Supplementation with Cordyceps CS-4 Fermentation Product Promotes Fat Metabolism During Prolonged Exercise | 30 | CS-4 | 4500 mg/day | |
| 2004 | Ophiocordyceps sinensis | Randomized Double-blind Placebo-controlled Clinical Trial and Assessment of Fermentation Product of Cordyceps Sinensis (CS-4) in Enhancing Aerobic Capacity and Respiratory Function of The Healthy Elderly Volunteers | 37 | CS-4 | 3000 mg/day | |
| 2004 | Ophiocordyceps sinensis | CordyMax Enhances Aerobic Capability, Endurance Performance, and Exercise Metabolism in Healthy, Mid-Age to Elderly Sedentary Humans | 131 | CS-4 | 3000 mg/day | |
| 2004 | Ophiocordyceps sinensis | Cordyceps Sinensis (CordyMax CS-4) Supplementation Does Not Improve Endurance Exercise Performance | 22 | CS-4 | 3000 mg/day | |
| 2005 | Ophiocordyceps sinensis | Cordyceps sinensis- and Rhodiola rosea-based Supplementation in Male Cyclists and Its Effect on Muscle Tissue Oxygen Saturation | 8 | CS-4 | 1,000-2,000 mg/day | |
| 2009 | Ophiocordyceps sinensis | Randomized, Double-Blind, Placebo-Controlled Trial of Herbal Therapy for Children with Asthma | 85 | Mix including Myceliated Biomass (oats) | 0.619 g/day | |
| 2010 | Ophiocordyceps sinensis | Effect of CS-4 (Cordyceps sinensis) on Exercise Performance in Healthy Older Subjects: A Double-Blind, Placebo-Controlled Trial | 20 | CS-4 | 333 mg three times a day | |
| 2016 | Ophiocordyceps sinensis | Herbal Medicine Cordyceps sinensis Improves Health-Related Quality of Life in Moderate-to-Severe Asthma | | Fruiting Body | 3600 mg/day | |
| 2019 | Ophiocordyceps sinensis | Immunomodulatory effects of a β-glucan of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial | 79 | β-glucan extract | 1.68 g/day | |
| 2021 | Ophiocordyceps sinensis | Applying Cordyceps sinensis to Boost Endurance Performance in Long-Distance Runners | 12 | – | Not specified | |
| 2022 | Ophiocordyceps sinensis | Effects of cordyceps sinensis supplementation during 12 weeks in amateur marathoners: A randomized, double-blind placebo-controlled trial | 30 | Fruiting Body | 2000 mg/day | |
| 2024 | Ophiocordyceps sinensis | Randomized Double-blind Placebo-controlled Clinical Trial and Assessment of Fermentation Product of Cordyceps Sinensis in Enhancing Aerobic Capacity and Respiratory Function of The Healthy Elderly Volunteers | 37 | CS-4 | – | |
| 1995 | Reishi (Ganoderma lucidum) | Sensitization to Ganoderma lucidum in Patients with Respiratory Allergy in India | 172 | Fruitng Body and Spore Extract | – | |
| 2002 | Reishi (Ganoderma lucidum) | A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. Extract (Ganopofy) in Patients with Advanced Cancer | 143 | Ganopoly (β-glucan extract) | 5400 mg/day | |
| 2002 | Reishi (Ganoderma lucidum) | A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) Extract in Patients with Chronic Hepatitis B | 90 | Ganopoly (β-glucan extract) | – | |
| 2003 | Reishi (Ganoderma lucidum) | Effects of Ganopoly1 (A Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-Stage Cancer Patients | 34 | Ganopoly (β-glucan extract) | 5400 mg/day | |
| 2003 | Reishi (Ganoderma lucidum) | A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly®) in Patients with Advanced Lung Cancer | 68 | Ganopoly (β-glucan extract) | 1800 mg/day | |
| 2004 | Reishi (Ganoderma lucidum) | A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus | 71 | Ganopoly (β-glucan extract) | 5400 mg/day | |
| 2004 | Reishi (Ganoderma lucidum) | A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Coronary Heart Disease | 168 | Ganopoly (β-glucan extract) | – | |
| 2005 | Reishi (Ganoderma lucidum) | Phase I Study of a Methanol Extract of Ganoderma lucidum, Edible and Medicinal Mushroom, in Men with Mild Symptoms of Bladder Outlet Obstruction | 50 | Methanol Extract | 0.6, 6, or 60 mg/day | |
| 2005 | Reishi (Ganoderma lucidum) | Immune Responses to Water-Soluble Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in Patients with Advanced Colorectal Cancer | 47 | Ganopoly (β-glucan extract) | 5400 mg/day | |
| 2005 | Reishi (Ganoderma lucidum) | Effects of Water-Soluble Ganoderma lucidum Polysaccharides on the Immune Functions of Patients with Advanced Lung Cancer | 36 | Ganopoly (β-glucan extract) | 5400 mg/day | |
| 2005 | Reishi (Ganoderma lucidum) | A Randomized, Double-Blind and Placebo-Controlled Study of a Ganoderma lucidum Polysaccharide Extract in Neurasthenia | 132 | Ganopoly (β-glucan extract) | 5400 mg/day | |
| 2005 | Reishi (Ganoderma lucidum) | A Prospective, Randomized, Double-Blind, Placebo-Controlled Study of the Platelet and Global Hemostatic Effects of Ganoderma Lucidum (Ling-Zhi) in Healthy Volunteers | 40 | Ganopoly (β-glucan extract) | 1500 mg/day | |
| 2007 | Reishi (Ganoderma lucidum) | Safety and Tolerability of Ganoderma lucidum in Healthy Subjects: A Double-Blind Randomized Placebo-Controlled Trial | 16 | Fruiting Body and Spore Extract | 4000 mg/day (1.89% terpenoids and 15.8% polysaccharides) | |
| 2007 | Reishi (Ganoderma lucidum) | Safety and Efficacy of Ganoderma lucidum (Lingzhi) and San Miao San Supplementation in Patients With Rheumatoid Arthritis: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial | 65 | Unspecified Extract | 4000 mg/day | |
| 2007 | Reishi (Ganoderma lucidum) | Potential Benefits of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) to Breast Cancer Patients | 1 | Triterpene-enriched polysaccharide extract | – | |
| 2007 | Reishi (Ganoderma lucidum) | Effect of an Extract of Ganoderma lucidum in Men with Lower Urinary Tract Symptoms: A Double-Blind, Placebo-Controlled Randomized and Dose-Ranging Study | 88 | Unspecified Extract | 0.6, 6, or 60 mg/day | |
| 2008 | Reishi (Ganoderma lucidum) | Randomized Clinical Trial of an Ethanol Extract of Ganoderma Lucidum in Men with Lower Urinary Tract Symptoms | 88 | Fruiting Body Alcohol Extract | 6 mg/day | |
| 2011 | Reishi (Ganoderma lucidum) | Study of Potential Cardioprotective Effects of Ganoderma Lucidum (Lingzhi): Results of a Controlled Human Intervention Trial | 26 | Unspecified Extract | 1440 mg/day | |
| 2011 | Reishi (Ganoderma lucidum) | Spore Powder of Ganoderma Lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial | 48 | Spore Powder | 3000 mg/day | |
| 2013 | Reishi (Ganoderma lucidum) | Preliminary Study of the Applications of Ganoderma Lucidum in Chronic Fatigue Syndrome | 50 | Unspecified Extract | 2000 mg/day | |
| 2014 | Reishi (Ganoderma lucidum) | Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial | 61 | Fruiting Body | 200 mg/day | |
| 2015 | Reishi (Ganoderma lucidum) | Useful Treatment of Severe Atopic Dermatitis with Ganoderma Lucidum: A Multiple-Case Study | 4 | Fruiting Body | 2700 mg/day | |
| 2015 | Reishi (Ganoderma lucidum) | A Randomized Double Blinded Study of Ganoderma lucidum (Lingzhi) in Salvage Setting of Recurrent Gynecologic Cancer | 60 | Fruiting Body + Spores Water Extract | 6000 mg/day | |
| 2016 | Reishi (Ganoderma lucidum) | A Double-Blind, Randomized, Placebo-Controlled Trial of Ganoderma lucidum for the Treatment of Cardiovascular Risk Factors of Metabolic Syndrome | 84 | 10:1 Fruiting Body Extract (75%) + Spores (25%) | 3000 mg/day | |
| 2017 | Reishi (Ganoderma lucidum) | Triterpenoids and Polysaccharide Peptides-Enriched Ganoderma Lucidum: A Randomized, Double-Blind Placebo-Controlled Crossover Study of Its Antioxidation and Hepatoprotective Efficacy in Healthy Volunteers | 42 | Extract (7% ganoderic acids and 6% β-Glucan) | 225 mg/day | |
| 2017 | Reishi (Ganoderma lucidum) | The Role of Ganoderma Lucidum Uptake on Some Hematological and Immunological Response in Patients with Coronavirus (COVID-19) | 150 | Unspecified Extract | – | |
| 2017 | Reishi (Ganoderma lucidum) | Cost-Utility Analysis of a Six-Weeks Ganoderma Lucidum-Based Treatment for Women with Fibromyalgia: A Randomized Double-Blind, Active Placebo-Controlled Trial | 26 | Micromilled Ganoderma lucidum | 6000 mg/day | |
| 2018 | Reishi (Ganoderma lucidum) | Spore Powder of Ganoderma Lucidum for the Treatment of Alzheimer Disease: A Pilot Study | 42 | Spore Powder | – | |
| 2018 | Reishi (Ganoderma lucidum) | Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellín, Colombia | 124 | β-glucans extract | – | |
| 2018 | Reishi (Ganoderma lucidum) | Immunostimulatory and Anti-inflammatory Effect of Ganoderma Lucidum on Breast Cancer Patients | 40 | Ganoderma Lucidum capsules | 2000 mg/day | |
| 2019 | Reishi (Ganoderma lucidum) | β-1,3/1,6-d-glucan Of Indonesian Ganoderma Lucidum β-glucan Reduces Systolic Blood Pressure & Inflammation In Hypertensive Patients | 50 | β-glucan extract | 540 mg/day | |
| 2020 | Reishi (Ganoderma lucidum) | Transarterial Chemoembolization in Hepatocellular Carcinoma: A Clinical Efficacy Study of Ganoderma Lucidum Extract Polysaccharide Peptide β-Glucan | 63 | β-glucan extract | – | |
| 2020 | Reishi (Ganoderma lucidum) | Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation | 38 | PPGL (β-glucan extract) | 750 mg/day | |
| 2020 | Reishi (Ganoderma lucidum) | Ganoderma Lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia | 64 | Fruiting Body | 6000 mg/day | |
| 2020 | Reishi (Ganoderma lucidum) | Effects of a Combination of Elderberry and Reishi Extracts on the Duration and Severity of Respiratory Tract Infections in Elderly Subjects: A Randomized Controlled Trial | 60 | Fruiting Body (standardized to 35% polysaccharides) | 500 mg/day | |
| 2020 | Reishi (Ganoderma lucidum) | Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients | 120 | Spore Powder | 4000 mg/day | |
| 2021 | Reishi (Ganoderma lucidum) | A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum) | 29 | Fruiting Body + Extract | – | |
| 2022 | Reishi (Ganoderma lucidum) | Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial | 135 | β-glucan extract | 200 mg/day | |
| 2022 | Reishi (Ganoderma lucidum) | The Efficacy of Ganoderma lucidum in Overweight Individuals: A Randomized Placebo-controlled trial | 72 | Fruiting Body + Extract | 780 mg/day | |
| 2022 | Reishi (Ganoderma lucidum) | The Potential Activity of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), to Alleviate Liver Injury in Adults with Acute Mushroom Poisoning: A Retrospective Study | 61 | – | – | |
| 2023 | Reishi (Ganoderma lucidum) | Combination Treatment in Ulcerative Colitis Using 5-Aminosalysilic Acid (5-ASA) and Polysaccharide Peptide of Indonesian Ganoderma lucidum β-glucan | 124 | PPGL (β-glucan extract) | 540 mg/day | |
| 2023 | Reishi (Ganoderma lucidum) | Medicinal Mushroom, Ganoderma Lucidum, Improves Painful Symptoms in Patients with Restless Legs Syndrome | 20 | Unspecified Extract | 920 mg/day | |
| 2024 | Reishi (Ganoderma lucidum) | Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study | 142 | Spore Powder | – | |
| 1992 | Shiitake (Lentinula edodes) | Immunological Analysis and Clinical Effects of Intraabdominal and Intrapleural Injection of Lentinan for Malignant Ascites and Pleural Effusion | 16 | Lentinan | 4 mg/week intracavitary injection | |
| 1992 | Shiitake (Lentinula edodes) | Enhanced Production of Interleukin 1 and Tumor Necrosis Factor by Peripheral Monocytes After Lentinan Administration in Patients with Gastric Carcinoma | 10 | Lentinan | 2 mg intravenously | |
| 1992 | Shiitake (Lentinula edodes) | Enhanced Induction of Lymphokine-Activated Killer Activity After Lentinan Administration in Patients with Gastric Carcinoma | 15 | Lentinan | 2 mg intravenously | |
| 1998 | Shiitake (Lentinula edodes) | Eosinophilia and Gastrointestinal Symptoms After Ingestion of Shiitake Mushrooms | 10 | Fruiting Body | 4000 mg/day | |
| 1998 | Shiitake (Lentinula edodes) | A Placebo-Controlled Trial of the Immune Modulator, Lentinan, in HIV-Positive Patients: A Phase I/II Trial | 98 | Lentinan | 10, 5, 2, or 1 mg/day | |
| 1999 | Shiitake (Lentinula edodes) | The preoperative administration of lentinan ameliorated the impairment of natural killer activity after cardiopulmonary bypass | 25 | Lentinan | 2mg/day intravenously | |
| 2002 | Shiitake (Lentinula edodes) | Effects of a Mushroom β-glucan on the Treatment of Prostate Cancer | 62 | β-glucan extract | ≈1000mg/10kg BW | |
| 2006 | Shiitake (Lentinula edodes) | Efficacy of Lentinan Combined with Chemotherapy in Advanced Non-Small Cell Lung Cancer | 81 | Lentinan | – | |
| 2008 | Shiitake (Lentinula edodes) | Clinical Application of a Combination Therapy of Lentinan, Multi-Electrode RFA and TACE in HCC | 78 | Lentinan | 500 mg/day | |
| 2010 | Shiitake (Lentinula edodes) | Dietary Administration of Mushroom β-glucans in Patients with Early Stage Prostate Cancers Managed Expectantly: A Phase II Study | 74 | AHCC (β-glucan extract) | 4500 mg/day | |
| 2010 | Shiitake (Lentinula edodes) | Efficacy of Orally Administered Superfine Dispersed Lentinan (β-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer | 80 | SDL (Superfine dispersed lentinan) | 15 mg/day | |
| 2011 | Shiitake (Lentinula edodes) | Supplementation with a Soluble Beta-Glucan Exported from Shiitake Medicinal Mushroom, Lentinus edodes (Berk.) Singer Mycelium: a Crossover, Placebo-Controlled Study in Healthy Elderly | 42 | Lentinan | 2.5 mg/day | |
| 2011 | Shiitake (Lentinula edodes) | Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy | 68 | Lentinan | – | |
| 2011 | Shiitake (Lentinula edodes) | Efficacy of Orally Administered Lentinula edodes Mycelia Extract for Advanced Gastrointestinal Cancer Patients Undergoing Cancer Chemotherapy- a Pilot Study | 8 | β-glucan extract | – | |
| 2011 | Shiitake (Lentinula edodes) | Efficacy and Safety of Orally Administered Lentinula edodes Mycelia Extract for Patients Undergoing Cancer Chemotherapy: A Pilot Study | 7 | β-glucan extract | 1800 mg/day | |
| 2011 | Shiitake (Lentinula edodes) | Combination therapy with lentinan improves outcomes in patients with esophageal carcinoma | 50 | Lentinan | 1 mg | |
| 2011 | Shiitake (Lentinula edodes) | Clinical observation of thermotherapy combined with thoracic injection of lentinan in treatment of cancerous hydrothorax of patients with lung cancer | 60 | Lentinan (β-glucan extract) | – | |
| 2011 | Shiitake (Lentinula edodes) | Testing a Low Molecular Mass Fraction of a Mushroom (Lentinus edodes) Extract Formulated as an Oral Rinse in a Cohort of Volunteers | 90 | Fruiting Body Extract | – | |
| 2012 | Shiitake (Lentinula edodes) | The Anticaries Effect of a Food Extract (Shiitake) in a Short-Term Clinical Study | 30 | Fruiting Body Extract | – | |
| 2012 | Shiitake (Lentinula edodes) | The Effect of Lentinan Combination Therapy for Unresectable Advanced Gastric Cancer | 39 | Lentinan | 2 mg | |
| 2013 | Shiitake (Lentinula edodes) | Efficacy of Oral Administration of Lentinula edodes Mycelia Extract for Breast Cancer Patients Undergoing Postoperative Hormone Therapy | 20 | β-glucan extract | 1800 mg | |
| 2014 | Shiitake (Lentinula edodes) | Dietary Supplementation with Rice Bran Fermented with Lentinus edodes Increases Interferon-\u03b3 Activity without Causing Adverse Effects: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study | 80 | Mycelliated Substrate | 3000 mg/day | |
| 2015 | Shiitake (Lentinula edodes) | Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults | 52 | Fruiting Body | 5 or 10 g/day | |
| 2016 | Shiitake (Lentinula edodes) | Randomized phase III study of S-1 alone versus S-1 plus lentinan for unresectable or recurrent gastric cancer | 309 | Lentinan | 2 mg/body | |
| 2016 | Shiitake (Lentinula edodes) | Polysaccharide from Lentinus edodes for Integrative Cancer Treatment: Immunomodulatory Effects on Lymphocyte Population | 7 | AHCC (β-glucan extract) | 300 mg/day | |
| 2016 | Shiitake (Lentinula edodes) | Improvement of QOL and Immunological Function With Lentinula Edodes Mycelia in Patients Undergoing Cancer Immunotherapy: An Open Pilot Study | 10 | Randomized phase III study of S-1 alone versus S-1 plus lentinan for unresectable or recurrent gastric cancer | 1800 mg/d | |
| 2016 | Shiitake (Lentinula edodes) | Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases | 12 | Lentinan | 2 mg | |
| 2016 | Shiitake (Lentinula edodes) | A phase II study of a combination treatment of alternate-day S-1 and lentinan as first-line chemotherapy for unresectable or recurrent gastric cancer | 37 | Lentinan | 2 mg/body | |
| 2017 | Shiitake (Lentinula edodes) | Lentinula edodes mycelia extract plus adjuvant chemotherapy for breast cancer patients: Results of a randomized study on host quality of life and immune function improvement | 47 | β-glucan extract | 1,800 mg/day | |
| 2018 | Shiitake (Lentinula edodes) | Immunomodulatory Effect of Lentinan on Aberrant T Subsets and Cytokines Profile in Non-small Cell Lung Cancer Patients | 73 | Lentinan | 4 mg/day | |
| 2018 | Shiitake (Lentinula edodes) | Clinical effects of lentinan combined with budesonide inhalation in treating acute exacerbation of chronic obstructive pulmonary disease under mechanical ventilation | 72 | Lentinan | 0.5 g | |
| 2018 | Shiitake (Lentinula edodes) | Lentinan combined with cisplatin and paclitaxel in the treatment of patients with ovarian cancer with ascites | 212 | Lentinan | – | |
| 2019 | Shiitake (Lentinula edodes) | An open label trial of a standardized extract of cultured Lentinula edodes mycelia (ECLM) in children with refractory epilepsy | 18 | β-glucan extract | 0.6 g/day | |
| 2020 | Shiitake (Lentinula edodes) | S-1 Plus Leucovorin and Oxaliplatin in Combination with Lentinan as First-line Therapy in Patients with Metastatic Gastric Cancer | 12 | Lentinan | – | |
| 2020 | Shiitake (Lentinula edodes) | A Quality-of-Life Study in Healthy Adults Supplemented with Lentinex\u00ae Beta-Glucan of Shiitake Culinary\u2212Medicinal Mushroom, Lentinus edodes (Agaricomycetes) | 63 | Lentinan | 1-2 mg | |
| 2020 | Shiitake (Lentinula edodes) | Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC\u00ae and Azithromycin in Healthy Individuals | 40 | AHCC (β-glucan extract) | – | |
| 2021 | Shiitake (Lentinula edodes) | Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia | 29 | AHCC (β-glucan extract) | 1000 mg | |
| 2021 | Shiitake (Lentinula edodes) | Modulation of human intestinal microbiota in a clinical trial by consumption of a \u03b2\u2010d\u2010glucan\u2010enriched extract obtained from Lentinula edodes | 52 | Fruiting Body Extract | 3.5 g/day | |
| 2021 | Shiitake (Lentinula edodes) | Lentinan Combined with (125)I Brachytherapy for Recurrent Ovarian Cancer | 160 | Lentinan | – | |
| 2021 | Shiitake (Lentinula edodes) | Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial | 68 | Fruiting Body | – | |
| 2023 | Shiitake (Lentinula edodes) | Safety and efficacy of lentinan nasal drops in patients infected with the variant of COVID-19: a randomized, placebo-controlled trial | 70 | Lentinan | 100 mg/day | |
| 2023 | Shiitake (Lentinula edodes) | Efficacy of Lentinula edodes Mycelia Extract on Chemotherapy-Related Tasted Disorders in Pancreatic Cancer Patients | 98 | AHCC (β-glucan extract) | – | |
| 2017 | Turkey Tail (Coriolus versicolor) | Coriolus versicolor (Yunzhi) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy | 15 | PSP(β-glucan extract) | 2.4 g g/day | |
| 2022 | Turkey Tail (Coriolus versicolor) | Efficacy of a Coriolus versicolor-Based Vaginal Gel in Human Papillomavirus-Positive Women Older Than 40 Years: A Sub-Analysis of PALOMA Study | 41 | Topical Gel (Papilocare®) | Papilocare® vaginal gel once daily for 21 days, followed by 7 days rest, for 1 or 3 months. Then, alternate-day therapy for 5 or 3 months. | |
| 1986 | Turkey Tail (Trametes versicolor) | Clinical results of a randomized controlled trial on the effect of adjuvant immunochemotherapy using Esquinon and Krestin in patients with curatively resected gastric cancer | 279 | PSK (β-glucan extract) | 2000 mg/m2/day | |
| 1988 | Turkey Tail (Trametes versicolor) | Clinical effect of postoperative adjuvant immunochemotherapy with the FT-207 suppository and PSK in colorectal cancer patients | 124 | PSK (β-glucan extract) | 3000 mg/day | |
| 1988 | Turkey Tail (Trametes versicolor) | Postoperative Adjuvant Immunochemotherapy with Mitomycin Futraful and PSK for Gastric Cancer | 579 | PSK (β-glucan extract) | 3000 mg/day | |
| 1989 | Turkey Tail (Trametes versicolor) | Adjuvant PSK Immunotherapy in Patients with Carcinoma of the Nasopharynx | 38 | PSK (β-glucan extract) | 1000 mg/day | |
| 1989 | Turkey Tail (Trametes versicolor) | An effect of adjuvant immunochemotherapy using krestin and 5-FU on gastric cancer patients with radical surgery (first report)–a randomized controlled trial by the cooperative study group | 262 | PSK (β-glucan extract) | 3000 mg/day | |
| 1990 | Turkey Tail (Trametes versicolor) | Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer | 111 | PSK (β-glucan extract) | 3000 mg/day followed 2/g day | |
| 1992 | Turkey Tail (Trametes versicolor) | Randomized Adjuvant Trial to Evaluate the Addition of Tamoxifen and PSK to Chemotherapy in Patients with Primary Breast Cancer | 967 | PSK (β-glucan extract) | – | |
| 1992 | Turkey Tail (Trametes versicolor) | Randomized, Controlled Study on Adjuvant Immunochemotherapy with PSK in Curatively Resected Colorectal Cancer | 448 | PSK (β-glucan extract) | – | |
| 1993 | Turkey Tail (Trametes versicolor) | Effect of krestin PSK as Adjuvant Treatment on the Prognosis after Radical Radiotherapy in Patients with Non-Small Cell Lung Cancer | 185 | PSK (β-glucan extract) | – | |
| 1994 | Turkey Tail (Trametes versicolor) | Efficacy of Immunochemotherapy as Adjuvant Treatment after Curative Resection of Gastric Cancer | 262 | PSK (β-glucan extract) | – | |
| 1994 | Turkey Tail (Trametes versicolor) | Oxidative Stress Relief for Cancer-Bearing Hosts by the Protein-Bound Polysaccharide of Coriolus versicolor QUEL with SOD Mimicking Activity | 18 | PSK (β-glucan extract) | 3000 mg/day | |
| 1995 | Turkey Tail (Trametes versicolor) | Immunochemotherapies versus Chemotherapy as Adjuvant Treatment after Curative Resection of Operable Breast Cancer | 227 | PSK (β-glucan extract) | – | |
| 1995 | Turkey Tail (Trametes versicolor) | Immunotherapy for Esophageal Cancer: A Randomized Trial in Combination with Radiotherapy and Radiochemotherapy | 174 | PSK (β-glucan extract) | – | |
| 1996 | Turkey Tail (Trametes versicolor) | Postoperative Adjuvant Randomised Trial Comparing Chemoendocrine Therapy, Chemotherapy and Immunotherapy for Patients with Stage II Breast Cancer: 5-year Results | 916 | PSK (β-glucan extract) | 3000 mg/day | |
| 1997 | Turkey Tail (Trametes versicolor) | HLA Antigen as Predictive Index for the Outcome of Breast Cancer Patients with Adjuvant Immunochemotherapy with PSK | 134 | PSK (β-glucan extract) | 3000 mg/day | |
| 2003 | Turkey Tail (Trametes versicolor) | Adjuvant Therapy With Protein-Bound Polysaccharide K and Tegafur Uracil in Patients With Stage II or III Colorectal Cancer: Randomized, Controlled Trial | 201 | PSK (β-glucan extract) | 3000 mg/day | |
| 2003 | Turkey Tail (Trametes versicolor) | Coriolus versicolor Polysaccharide Peptide Slows Progression of Advanced Non-Small Cell Lung Cancer | 68 | PSP(β-glucan extract) | 3060 mg/day | |
| 2004 | Turkey Tail (Trametes versicolor) | Adjuvant Immunochemotherapy with Oral Tegafur/Uracil Plus PSK in Patients with Stage II or III Colorectal Cancer: A Randomized Controlled Study | 205 | PSK (β-glucan extract) | 3000 mg/day | |
| 2004 | Turkey Tail (Trametes versicolor) | Effect of Adjuvant Immunochemotherapy with PSK for Colon Cancer Patients Showing Oncogenic \u03b2-Catenin Activation in Primary Tumor | 202 | PSK (β-glucan extract) | 3000 mg/day | |
| 2004 | Turkey Tail (Trametes versicolor) | Long-term Effect of 5-Fluorouracil Enhanced by Intermittent Administration of Polysaccharide K after Curative Resection of Colon Cancer: A Randomized Controlled Trial for 7-Year Follow-up | 446 | PSK (β-glucan extract) | 3000 mg/day | |
| 2004 | Turkey Tail (Trametes versicolor) | Immunomodulatory Effects of Yun Zhi and Danshen Capsules in Healthy Subjects—a Randomized, Double-Blind, Placebo-Controlled, Crossover Study | 100 | PSP(β-glucan extract) | 50 mg/kg body weight | |
| 2005 | Turkey Tail (Trametes versicolor) | Immunomodulatory Activities of Yunzhi and Danshen in Post-treatment Breast Cancer Patients | 82 | PSP(β-glucan extract) | 50 mg/kg body weight | |
| 2006 | Turkey Tail (Trametes versicolor) | Beneficial Effects of Protein-Bound Polysaccharide K Plus Tegafur/Uracil in Patients with Stage II or III Colorectal Cancer: Analysis of Immunological Parameters | 205 | PSK (β-glucan extract) | 3000 mg/day | |
| 2006 | Turkey Tail (Trametes versicolor) | Clinical Studies of Immunomodulatory Activities of Yunzhi-Danshen in Patients with Nasopharyngeal Carcinoma | 27 | PSK (β-glucan extract) | 3600 mg/day | |
| 2007 | Turkey Tail (Trametes versicolor) | Adjuvant Immunochemotherapy with Protein-Bound Polysaccharide K for Colon Cancer in Relation to Oncogenic β-Catenin Activation | 202 | PSK (β-glucan extract) | – | |
| 2007 | Turkey Tail (Trametes versicolor) | In vivo effect of I’m-Yunity on hepatic cytochrome P450 3A4 | 12 | PSP(β-glucan extract) | – | |
| 2012 | Turkey Tail (Trametes versicolor) | Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer | 11 | Myceliated Substrate (not specified; from fungi perfecti) | 3, 6, or 9 g/day | |
| 2014 | Turkey Tail (Trametes versicolor) | Effects of polysaccharopeptide from Trametes Versicolor and amoxicillin on the gut microbiome of healthy volunteers | 24 | PSP(β-glucan extract) | – | |
| 2017 | Turkey Tail (Trametes versicolor) | Phase III Trial Comparing UFT + to UFT + LV in Stage IIB, III Colorectal Cancer | 357 | PSK (β-glucan extract) | 3000 mg/day | |
| 2017 | Turkey Tail (Trametes versicolor) | Randomized Phase III Trial Comparing Surgery Alone to UFT+ PS for Stage II Rectal Cancer (JFMC38 Trial) | 111 | PSK (β-glucan extract) | 3000 mg/day | |
| 2024 | Turkey Tail (Trametes versicolor) | Adjuvant Chemotherapy With UFT/LV Versus UFT/LV Plus PSK in Stage II/III Colorectal Cancer | 186 | PSK (β-glucan extract) | 3000 mg/day | |
| 2011 | (specific compound) | The Bioavailability of Ergothioneine from Mushrooms and Effects on Antioxidant Capacity and Inflammation | 10 | Ergothioneine | 8g or 16g mushroom powder | |
| 2012 | (specific compound) | Improvement of Joint ROM and Reduction of Chronic Pain with Ergothioneine-Containing Supplement | 12 | Ergothioneine | Unspecified | |
| 2014 | (specific compound) | Clinical and Biochemical Correlates of Serum L-Ergothioneine | 439 | Ergothioneine | Observational study (no supplementation) | |
| 2017 | (specific compound) | Administration of Pure Ergothioneine to Healthy Subjects | 47 | Ergothioneine | 5 mg and 25 mg daily | |
| 2022 | (specific compound) | Low Plasma Ergothioneine Predicts Cognitive and Functional Decline in the Elderly | 470 | Ergothioneine | Observational study (no supplementation) | |
| 2024 | (specific compound) | Investigating Ergothioneine to Delay Cognitive Decline in Mild Cognitively Impaired Subjects | 19 | Ergothioneine | 25 mg 3 times per week | |
| 2023 | Tremella fuciformis | Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial | 64 | Fruiting Body Extract | 56 mg/day for 8 weeks | |
| 2012 | Tremella mesenterica | Yellow brain culinary-medicinal mushroom, Tremella mesenterica Ritz.:Fr. (higher Basidiomycetes), is subjectively but not objectively effective for eradication of Helicobacter pylori: a prospective controlled trial | 52 | Fruiting Body Extract | 4 g/day for 10 days | |
| 2018 | Tremella fuciformis | Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment: A Randomized Controlled TrialEdit | Quick Edit | Trash | View | 75 | Fruiting Body Extract | 600 or 1200 mg/day | |
