Reishi Mushroom
Ganoderma lucidum
Reishi (Ganoderma linghzi) is one of the most studied and widely used functional mushrooms on the planet. It has been used in Traditional Chinese Medicine for thousands of years, where it’s believed to improve longevity, youth, and overall vitality.
Modern research has revealed that the Reishi mushroom contains a variety of bioactive compounds, including polysaccharides, triterpenoids, and antioxidants, that may be responsible for its purported health benefits. It’s immune-boosting properties have been of particular interest to researchers, especially in the context of cancer therapies. Other studies suggest Reishi may reduce inflammation, protect the liver, improve sleep, and lower blood sugar levels.
Keep on reading to learn about the bioactive compounds, how it works, and what the clinical research says.
Health Benefits Of Reishi Mushroom
Research, including preclinical studies (in vitro, animal) and some human clinical trials, suggests Reishi may possess several potential benefits, primarily attributed to its rich array of bioactive compounds like polysaccharides (especially beta-glucans) and triterpenoids (ganoderic acids). Key areas of investigation include:
- Immunomodulation: Beta-glucans are known to interact with immune cells, potentially enhancing or balancing immune responses.
- Sleep Support: Some studies and anecdotal reports suggest Reishi may promote relaxation and improve sleep quality, possibly via modulation of the nervous system.
- Cardiovascular Support: Preliminary research indicates potential benefits related to blood pressure regulation and cholesterol management.
- Antioxidant Activity: Reishi contains compounds that can help neutralize harmful free radicals, potentially reducing oxidative stress.
- Other Areas: Research also explores potential roles in liver support, blood sugar management, and adjunct support in oncology (always consult an oncologist). It is crucial to note that while research is promising, robust, large-scale human trials are still needed to fully understand it’s use, dosage, and long-term benefits.
Beneficial Compounds
Beta-Glucans

Beta-glucans are a type of polysaccharide that have been studied for their potential to stimulate the immune system and fight cancer cells. Beta-glucans are work by activating various immune cells via specialized receptors, leading to the production of cytokines and other signaling molecules that help to coordinate the immune response. While more research is needed, Reishi polysaccharides may offer promising immunomodulatory and antitumor effects.
Triterpenoids

In Reishi mushrooms, triterpenoids are responsible for the mushroom’s bitter taste and have been shown to have anti-inflammatory, antioxidant, and liver-protective effects. They may also help to lower blood pressure and cholesterol levels. Ganoderic acids, a type of triterpenoid found in Reishi, have been specifically investigated for their potential to inhibit tumor growth and metastasis.
Ergosterol

Ergosterol is a natural compound found in mushrooms that has various medicinal benefits. It is a type of sterol that is similar to cholesterol in animals and is a precursor to vitamin D2, which is essential for calcium absorption and bone health. Ergosterol has been shown to have antioxidant, anti-inflammatory, anticancer, antidiabetic, and neuroprotective effects. It may also help to improve liver health, boost the immune system, and protect against infectious diseases.
Clinical Trials
The clinical trials conduct on Reishi highlight the diverse applications of reishi, ranging from cancer support to metabolic health and immune modulation. They utilized various forms of reishi, including spore powder, extracts, and whole mushroom preparations.

Reishi Mushroom Dosage Guidelines
Like any drug or herbal medicine, dosage is a key component to effective treatment. When it comes to Reishi mushroom dosages, these can vary widely depending on the form in which your consuming it and your specific condition. Generally speaking, dosages vary anywhere from 500 mg to over 5000 mg per day for a 1:1 fruiting body extract.
Factors Influencing Dosage
Potency: Potency refers to how concentrated a product is. More specifically, it can be thought of how many bioactive compounds it contains. For example, beta-glucans (a key bioactive comppound) can range from just a couple percentage points in low-quality products, to 30-40% in good products, and above 80% in highly refined products utilized in clinical settings. We highly reccomend you check out our supplement buying guide to make sure you invest in a good product.
Condition: Serious conditions generally require larger doses that range up to 3-5 grams (for a good product.) For less serious conditions, or for general well-being, 1 gram is usually reccomended as a base.
Treatment: While it’s not very well studied, you may choose to take Reishi along with other herbs/medication. While Reishi is regarded as safe and has not been shown to have serious contradictions, the efficacy of mixed treatments has not been well studied.
How Much Reishi Mushroom Should You Take?
As mentioned above, there can be many factors influencing the dosage. Below are some reccomended guidelines for a high quality 1:1 fruiting body extract powder. |
General Well Being and Prevention: 500-1500 mg per day
If all you’re looking for is to improve your well-being or reduce how often you get sick, it’s generally reccomended to consume atleast 1000mg. You can get away with doses aslow as 500 mg but they will be less effective.
Mild to Chronic Conditions: >1000 mg per day
If you are trying to improve a certain condition, such as allergies, bad sleep, irratibility, ect. you should take at least 1000 mg. Taking more will usually improve results.
Serious Illness: >3000-5000 mg per day
If you are suffering from a serious or potentially life thereatening illness, you should consult your doctor. Reishi on it’s own is not considered a cure for anything, although it could improve the results of certain treatments. Taking over 5000 mg is not unheard of for some illnesses.
Frequently Asked Questions About Reishi Mushrooms
What is Reishi Mushroom?
Reishi, scientifically known as Ganoderma lucidum, is a polypore fungus characterized by its distinct kidney- or fan-shaped, reddish-brown, varnished-looking cap and woody texture. It typically grows on decaying hardwoods. For centuries, it has been used in Traditional Chinese Medicine (TCM) and other systems for promoting health and longevity. It is now cultivated globally for use in dietary supplements and functional foods.
What Does Reishi Mushroom Feel Like?
Reishi is not a psychoactive substance like stimulant or sedative drugs, nor does it produce euphoria or an immediate, pronounced ‘feeling’ for most users. Its effects are generally subtle and cumulative, often described as promoting a sense of calmness, reduced stress, or enhanced relaxation over time with consistent use. Some individuals may notice improvements in sleep quality. It does not impair cognitive function or cause drowsiness during the day for most people when used appropriately. Effects are highly individual.
How Long Does It Take to Feel the Effects of Reishi?
Reishi’s effects are typically gradual and cumulative, not immediate. As an adaptogen and immunomodulator, its benefits often build over weeks or months of consistent daily use. Subtle effects like improved relaxation or sleep quality might be noticed by some individuals within hours, days or a few weeks.
Does Reishi Have Side Effects?
Reishi is generally considered safe for most healthy adults when taken appropriately. Phase 1 Clinical Studies which investigate safetyness of Reishi have not found any significant side effects or dangers. Some users report dryness of the mouth due to the bitter and slightly astringent nature.
Is Reishi Dangerous?
For most healthy individuals, Reishi is not considered dangerous when sourced responsibly and used correctly. However, caution and avoidance are warranted in specific situations. If you have any serious condition ALWAYS consult your doctor when adding anything into your treament. Please utilize caution if you have a bleeding disorder, are going into surgery, have low blood pressure, autoimmune diseases, are pregenant or breastfeeding, or have allergies.
Is Reishi Hallucinogenic?
No, absolutely not. Reishi mushroom does not contain psilocybin, psilocin, or any other compounds known to cause hallucinogenic or psychedelic effects. It does not alter perception, induce visions, or create the altered states of consciousness associated with “magic mushrooms.” Confusion sometimes arises due to the general term “mushrooms,” but Reishi’s pharmacological profile is entirely different.