Effects of Antrodia camphorata Mycelia Extract Containing Antroquinonol on Lowering Low-Density Lipoprotein Cholesterol: A Randomized Double-Blind Study

Authors: Miles Chih-Ming Chen, Pei-Ni Chen, Howard Hao-Yu Cheng, Wayne Ching-Cheng Wei, Ryuji Takeda, Mitsuko Mori, and Kiichiro Mochida

Journal: Journal of Pharmacy and Nutrition Sciences

Study Design: Randomized, double-blind, placebo-controlled trial

Participants: 26 subjects with borderline or mildly elevated LDL cholesterol levels

Trial Length: 12 weeks

Intervention:

• Treatment group: One tablet per day containing 25 mg of Antrodia camphorata mycelia extract (antroquinonol: 0.68 mg)
• Placebo group: One tablet per day containing placebo

Outcome Measures:

• LDL cholesterol
• Total cholesterol

Summary:

The study examined the effects of Antrodia camphorata mycelia extract on LDL cholesterol levels in humans. Participants with borderline or mildly elevated LDL cholesterol levels were randomly assigned to receive either the extract or a placebo for 12 weeks. The results showed a significant reduction in LDL cholesterol in the treatment group compared to the placebo group. Additionally, the treatment group showed a tendency towards reduced total cholesterol. The study concluded that Antrodia camphorata mycelia extract effectively lowers LDL cholesterol in individuals with somewhat high LDL cholesterol levels.