| 1995 | Reishi (Ganoderma lucidum) | Sensitization to Ganoderma lucidum in Patients with Respiratory Allergy in India | 172 | Fruitng Body and Spore Extract | – |
| 2002 | Reishi (Ganoderma lucidum) | A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. Extract (Ganopofy) in Patients with Advanced Cancer | 143 | Ganopoly (β-glucan extract) | 5400 mg/day |
| 2002 | Reishi (Ganoderma lucidum) | A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) Extract in Patients with Chronic Hepatitis B | 90 | Ganopoly (β-glucan extract) | – |
| 2003 | Reishi (Ganoderma lucidum) | Effects of Ganopoly1 (A Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced-Stage Cancer Patients | 34 | Ganopoly (β-glucan extract) | 5400 mg/day |
| 2003 | Reishi (Ganoderma lucidum) | A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly®) in Patients with Advanced Lung Cancer | 68 | Ganopoly (β-glucan extract) | 1800 mg/day |
| 2004 | Reishi (Ganoderma lucidum) | A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus | 71 | Ganopoly (β-glucan extract) | 5400 mg/day |
| 2004 | Reishi (Ganoderma lucidum) | A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Coronary Heart Disease | 168 | Ganopoly (β-glucan extract) | – |
| 2005 | Reishi (Ganoderma lucidum) | Phase I Study of a Methanol Extract of Ganoderma lucidum, Edible and Medicinal Mushroom, in Men with Mild Symptoms of Bladder Outlet Obstruction | 50 | Methanol Extract | 0.6, 6, or 60 mg/day |
| 2005 | Reishi (Ganoderma lucidum) | Immune Responses to Water-Soluble Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in Patients with Advanced Colorectal Cancer | 47 | Ganopoly (β-glucan extract) | 5400 mg/day |
| 2005 | Reishi (Ganoderma lucidum) | Effects of Water-Soluble Ganoderma lucidum Polysaccharides on the Immune Functions of Patients with Advanced Lung Cancer | 36 | Ganopoly (β-glucan extract) | 5400 mg/day |
| 2005 | Reishi (Ganoderma lucidum) | A Randomized, Double-Blind and Placebo-Controlled Study of a Ganoderma lucidum Polysaccharide Extract in Neurasthenia | 132 | Ganopoly (β-glucan extract) | 5400 mg/day |
| 2005 | Reishi (Ganoderma lucidum) | A Prospective, Randomized, Double-Blind, Placebo-Controlled Study of the Platelet and Global Hemostatic Effects of Ganoderma Lucidum (Ling-Zhi) in Healthy Volunteers | 40 | Ganopoly (β-glucan extract) | 1500 mg/day |
| 2007 | Reishi (Ganoderma lucidum) | Safety and Tolerability of Ganoderma lucidum in Healthy Subjects: A Double-Blind Randomized Placebo-Controlled Trial | 16 | Fruiting Body and Spore Extract | 4000 mg/day (1.89% terpenoids and 15.8% polysaccharides) |
| 2007 | Reishi (Ganoderma lucidum) | Safety and Efficacy of Ganoderma lucidum (Lingzhi) and San Miao San Supplementation in Patients With Rheumatoid Arthritis: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial | 65 | Unspecified Extract | 4000 mg/day |
| 2007 | Reishi (Ganoderma lucidum) | Potential Benefits of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) to Breast Cancer Patients | 1 | Triterpene-enriched polysaccharide extract | – |
| 2007 | Reishi (Ganoderma lucidum) | Effect of an Extract of Ganoderma lucidum in Men with Lower Urinary Tract Symptoms: A Double-Blind, Placebo-Controlled Randomized and Dose-Ranging Study | 88 | Unspecified Extract | 0.6, 6, or 60 mg/day |
| 2008 | Reishi (Ganoderma lucidum) | Randomized Clinical Trial of an Ethanol Extract of Ganoderma Lucidum in Men with Lower Urinary Tract Symptoms | 88 | Fruiting Body Alcohol Extract | 6 mg/day |
| 2011 | Reishi (Ganoderma lucidum) | Study of Potential Cardioprotective Effects of Ganoderma Lucidum (Lingzhi): Results of a Controlled Human Intervention Trial | 26 | Unspecified Extract | 1440 mg/day |
| 2011 | Reishi (Ganoderma lucidum) | Spore Powder of Ganoderma Lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial | 48 | Spore Powder | 3000 mg/day |
| 2013 | Reishi (Ganoderma lucidum) | Preliminary Study of the Applications of Ganoderma Lucidum in Chronic Fatigue Syndrome | 50 | Unspecified Extract | 2000 mg/day |
| 2014 | Reishi (Ganoderma lucidum) | Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial | 61 | Fruiting Body | 200 mg/day |
| 2015 | Reishi (Ganoderma lucidum) | Useful Treatment of Severe Atopic Dermatitis with Ganoderma Lucidum: A Multiple-Case Study | 4 | Fruiting Body | 2700 mg/day |
| 2015 | Reishi (Ganoderma lucidum) | A Randomized Double Blinded Study of Ganoderma lucidum (Lingzhi) in Salvage Setting of Recurrent Gynecologic Cancer | 60 | Fruiting Body + Spores Water Extract | 6000 mg/day |
| 2016 | Reishi (Ganoderma lucidum) | A Double-Blind, Randomized, Placebo-Controlled Trial of Ganoderma lucidum for the Treatment of Cardiovascular Risk Factors of Metabolic Syndrome | 84 | 10:1 Fruiting Body Extract (75%) + Spores (25%) | 3000 mg/day |
| 2017 | Reishi (Ganoderma lucidum) | Triterpenoids and Polysaccharide Peptides-Enriched Ganoderma Lucidum: A Randomized, Double-Blind Placebo-Controlled Crossover Study of Its Antioxidation and Hepatoprotective Efficacy in Healthy Volunteers | 42 | Extract (7% ganoderic acids and 6% β-Glucan) | 225 mg/day |
| 2017 | Reishi (Ganoderma lucidum) | The Role of Ganoderma Lucidum Uptake on Some Hematological and Immunological Response in Patients with Coronavirus (COVID-19) | 150 | Unspecified Extract | – |
| 2017 | Reishi (Ganoderma lucidum) | Cost-Utility Analysis of a Six-Weeks Ganoderma Lucidum-Based Treatment for Women with Fibromyalgia: A Randomized Double-Blind, Active Placebo-Controlled Trial | 26 | Micromilled Ganoderma lucidum | 6000 mg/day |
| 2018 | Reishi (Ganoderma lucidum) | Spore Powder of Ganoderma Lucidum for the Treatment of Alzheimer Disease: A Pilot Study | 42 | Spore Powder | – |
| 2018 | Reishi (Ganoderma lucidum) | Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellín, Colombia | 124 | β-glucans extract | – |
| 2018 | Reishi (Ganoderma lucidum) | Immunostimulatory and Anti-inflammatory Effect of Ganoderma Lucidum on Breast Cancer Patients | 40 | Ganoderma Lucidum capsules | 2000 mg/day |
| 2019 | Reishi (Ganoderma lucidum) | β-1,3/1,6-d-glucan Of Indonesian Ganoderma Lucidum β-glucan Reduces Systolic Blood Pressure & Inflammation In Hypertensive Patients | 50 | β-glucan extract | 540 mg/day |
| 2020 | Reishi (Ganoderma lucidum) | Transarterial Chemoembolization in Hepatocellular Carcinoma: A Clinical Efficacy Study of Ganoderma Lucidum Extract Polysaccharide Peptide β-Glucan | 63 | β-glucan extract | – |
| 2020 | Reishi (Ganoderma lucidum) | Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation | 38 | PPGL (β-glucan extract) | 750 mg/day |
| 2020 | Reishi (Ganoderma lucidum) | Ganoderma Lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia | 64 | Fruiting Body | 6000 mg/day |
| 2020 | Reishi (Ganoderma lucidum) | Effects of a Combination of Elderberry and Reishi Extracts on the Duration and Severity of Respiratory Tract Infections in Elderly Subjects: A Randomized Controlled Trial | 60 | Fruiting Body (standardized to 35% polysaccharides) | 500 mg/day |
| 2020 | Reishi (Ganoderma lucidum) | Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients | 120 | Spore Powder | 4000 mg/day |
| 2021 | Reishi (Ganoderma lucidum) | A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum) | 29 | Fruiting Body + Extract | – |
| 2022 | Reishi (Ganoderma lucidum) | Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial | 135 | β-glucan extract | 200 mg/day |
| 2022 | Reishi (Ganoderma lucidum) | The Efficacy of Ganoderma lucidum in Overweight Individuals: A Randomized Placebo-controlled trial | 72 | Fruiting Body + Extract | 780 mg/day |
| 2022 | Reishi (Ganoderma lucidum) | The Potential Activity of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), to Alleviate Liver Injury in Adults with Acute Mushroom Poisoning: A Retrospective Study | 61 | – | – |
| 2023 | Reishi (Ganoderma lucidum) | Combination Treatment in Ulcerative Colitis Using 5-Aminosalysilic Acid (5-ASA) and Polysaccharide Peptide of Indonesian Ganoderma lucidum β-glucan | 124 | PPGL (β-glucan extract) | 540 mg/day |
| 2023 | Reishi (Ganoderma lucidum) | Medicinal Mushroom, Ganoderma Lucidum, Improves Painful Symptoms in Patients with Restless Legs Syndrome | 20 | Unspecified Extract | 920 mg/day |
| 2024 | Reishi (Ganoderma lucidum) | Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study | 142 | Spore Powder | – |
