Hepatoprotective Effect of Antrodia Cinnamomea Mycelia Extract in Subhealth Japanese Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

Authors: Chun-Yi Ho, Chen-Meng Kuan, Pang-Kuei Hsu

Journal: Journal of Dietary Supplements

Study Design: Randomized, double-blind, placebo-controlled clinical study

Participants: 44 subhealth Japanese adults (alanine aminotransferase (ALT) levels between 31 and 50 U/L and aspartate aminotransferase (AST) levels ≤50 U/L)

Trial Length: 12 weeks

Intervention:

• Treatment group: One capsule per day containing 250 mg of Antrodia cinnamomea mycelia extract (ACME) powder
• Placebo group: One capsule per day containing placebo

Outcome Measures:

• ALT and AST levels
• Adverse effects

Summary:

The study aimed to assess the ameliorating effects of ACME on liver health in subhealth Japanese adults. While the initial analysis showed no significant changes in ALT and AST levels between the ACME and placebo groups, subgroup analysis revealed that ACME significantly improved the mean ALT level in participants who consumed alcoholic drinks more than twice a week. No treatment-related adverse effects were observed. The study concluded that ACME may effectively improve liver health, particularly in regular drinkers. Sources and related content