Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial

Author: Bruno Donatini

Journal: International Journal of Medicinal Mushrooms

Study Design:

• Intervention:
  • Group 1: Laetiporus sulphureus (LS) 400 mg/day
  • Group 2: Trametes versicolor (TV) + Ganoderma lucidum (GL) 400 mg/day (200 mg of each)
• Participants: 61 patients with oral human papillomavirus (HPV) types 16 or 18
• Duration: 2 months
• Outcome Measure: Clearance of oral HPV16 or HPV18 infection (measured by PCR)

Summary: This preliminary study investigated the effects of medicinal mushrooms on oral HPV infection. After 2 months, the group receiving Trametes versicolor (TV) and Ganoderma lucidum (GL) showed an 88% clearance rate of HPV, while the group receiving Laetiporus sulphureus (LS) had only a 5% clearance rate. This suggests that the combination of TV and GL may be effective in clearing oral HPV infection. However, further research is needed to confirm these findings due to the small sample size and lack of blinding in this study.