How does Lions Mane work?
The primary active compounds identified in Lion’s Mane are hericenones and erinacines, which are believed to stimulate nerve growth factor (NGF) production. NGF plays a crucial role in neurons’ growth, maintenance, and survival, making Lion’s Mane a potential candidate for improving cognitive function and neurological health.
There are numerous types of Hericenones and Erinacines, each believed to have unique benefits. Erinacine A is currently the most well studied of these compounds. Aside from these, there are many other health-promoting compounds known from Lions Mane, and more are being discovered. You can learn more about Erinacines and Hericenones here.
Erinacines
Erinacines are a type of diterpenoid compound primarily isolated from the mycelium of the Lion’s Mane mushroom. They are known to stimulate the production of Nerve Growth Factor (NGF), a protein crucial for the survival and function of nerve cells. Erinacines, particularly Erinacine A, have been shown to promote NGF synthesis in the central nervous system, potentially contributing to the neuroprotective and cognitive benefits of Lion’s Mane.
Hericenones
Hericenones are a class of cyathane-type diterpenoid compounds mainly found in the fruiting bodies of the Lion’s Mane mushroom. Similar to erinacines, hericenones also demonstrate the ability to stimulate NGF production. However, their specific mechanisms and effects may differ from those of erinacines. Research suggests that hericenones may play a role in the mushroom’s anti-inflammatory, neuroprotective, and potentially cognitive-enhancing properties.
Other Beneficial Compounds
Beta glucans
Beta-glucans are a type of polysaccharide found in the cell walls of Lion’s Mane. They have been linked to various health benefits, including immune health.
Phenolics
Phenolic compounds are a group of antioxidants found in Lion’s Mane. They can protect cells from damage caused by free radicals, likely contributing to the mushroom’s anti-inflammatory and neuroprotective effects.
Erosterol
Ergosterol is a type of sterol found in the cell membranes of fungi, including the Lion’s Mane mushroom. It is a precursor to vitamin D2, which is essential for calcium absorption and bone health.
ergothioneine
Ergothioneine is a powerful antioxidant naturally found in mushrooms. It plays a critical role in cellular health and protection, potentially supporting immunity and longevity.
Lions Mane Clinical Trials
While the number of clinical trials conducted on Lion’s Mane is still relatively limited, the existing body of research provides promising insights into the therapeutic applications of Lion’s Mane. The clinical trials conducted thus far have employed diverse study designs, including randomized controlled trials, pilot studies, and observational studies, to investigate the effects of Lion’s Mane on various health conditions.
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