Transarterial Chemoembolization in Hepatocellular Carcinoma: A Clinical Efficacy Study of Ganoderma Lucidum Extract Polysaccharide Peptide β-Glucan

Authors: Bagaswoto Poedjomartono, Arif Faisal, Siti Nurjanah

Journal: Bali Medical Journal

Study Design:

• Intervention: Trans-arterial chemoembolization (TACE) + β-Glucan or placebo
• Participants: 63 patients with hepatocellular carcinoma (HCC)
• Duration: Not specified in the abstract
• Outcome Measures: Tumor response, survival rate, immune response (CD4, CD8, IL-2)

Summary: This study investigated the effect of β-Glucan, a polysaccharide peptide derived from Ganoderma lucidum, as an adjunct to TACE in patients with HCC. The study found that the addition of β-Glucan to TACE significantly improved the therapeutic response, with a higher proportion of patients experiencing complete or partial responses compared to the placebo group. Additionally, β-Glucan was associated with increased survival rates and enhanced immune response, as evidenced by elevated levels of CD4, CD8, and IL-2. These findings suggest that β-Glucan may be a promising adjunct therapy for HCC treatment.