Combination Treatment in Ulcerative Colitis Using 5-Aminosalysilic Acid (5-ASA) and Polysaccharide Peptide of Indonesian Ganoderma lucidum Mycelium Extract

Authors: Marcellus Simadibrata, Aditya Rachman, Felix Budimutiar, Paulus Simadibrata, Murdani Abdullah, Raja Mangatur Haloho, Anthony Eka Wijaya, Batara Bisuk, Shabrina Maharani, Dewi Mustikarani, Daniel Martin Simadibrata, Peter Sugita

Journal: The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Study Design:

• Intervention: 3 x 180 mg \u03b2-1,3/1,6-D-glucan (polysaccharide peptide of Ganoderma lucidum mycelium extract) daily in conjunction with 5-ASA tablets 3 to 4 x 500 mg daily
• Participants: 80 in the intervention group (5-ASA + PPGL) and 44 in the control group (5-ASA only)
• Duration: 90 days
• Outcome Measures: Abdominal pain, fecal calprotectin, fecal M2PK, and hemoglobin levels

Summary: This study explored the use of a Ganoderma lucidum extract (PPGL) alongside standard medication (5-ASA) for ulcerative colitis. The results showed that the combination of PPGL and 5-ASA was more effective than 5-ASA alone in reducing symptoms like abdominal pain and improving lab markers of inflammation and blood health. These benefits were seen consistently over 90 days of treatment.